SIP Fermentation System (Production Scale) 100-1000 liter

Capacity

100 L

200 L

300 L

500 L

1000 L

Total volume

120 L

268 L

360 L

700L

1500 L

Working volume

100 L

200 L

300 L

500 L

1000 L

Vessel and jacket maximum working pressure

3 bar (43.5 psig) / 3 bar (43.5 psig)

Type

Double layered fully enclosed capsule-type tank, with an outer temperature protective layer

Material

Direct contact to medium - 316L stainless steel; all others - 304 stainless steel

Surface finish

Interior polish ≦ 25 Ra/in (0.6 μm) Mechanical polishing; Electropolish optional
Exterior polish ≦ 32 Ra/in (0.8 μm) Mechanical polishing; Electropolish optional

Ports

Ports designed according to user requirements

Piping and valve materials

Parts that directly contact with the product/medium uses 316L stainless steel (≤25 Ra/in) internal polished tubing (BPE standard) :
A.) Internal EP polished diaphragm type pneumatic valve and manual valve (BPE standard)
B.) Tubing all welded with orbital welding
C.) Vessel bottom drain uses a diaphragm valve, to minimize dead volume
D.) Piping designed for ease of transfer to scale up (can be used as a seed fermentation system) or downstream process
 

Parts that do not directly contact product/medium
A.) Constructed with 304 stainless steel

Controller

12” color industrial touch screen

* User-friendly, graphical control interface
* Includes secure user accounts, with different levels of access
* Use stainless-steel controller cabinet (100 L and above only)
* Modularized and standardized design (Module Skid): ergonomically designed according to height, ease of vessel clean
   up,  and ease of extraction in relation to vessel bottom valve
* Includes maintenance page with system diagnostics
* All programmed setting values are automatically stored into the built-in memory; the settings will not be lost in case of
   power outage/interruption. When power is restored, the interrupted process will automatically resumed

Setting

* Automated sterilization process
* Automated fermentation program

DO

* Control range: 0-100%, adjustable

* Software electrode calibration, with automatic temperature compensation function
* Includes one (1) set of side-inserted stainless steel autoclavable DO electrode

* DO Stat features with intelligent feeding

pH

* PID control with adjustable deadband
* Control range 2.00 to 12.00 pH, ±0.01
* Calibration function with automatic temperature compensation function
* Includes one (1) set of side-inserted, autoclavable pH probe with stainless steel housing

* pH Stat features with intelligent feeding

Pump

* Built-in peristaltic pumps

* Each feeding pump can run adjustable 15-step program
* Each pump can be adjusted for speed, forward and backward direction, and manual or automatic mode
* Each of the four peristaltic pumps can be designated for different functions: acid pump, base pump, antifoam pump, or 
   substrate feeding pump
* Optional fifth and six peristaltic pump available

Temperature

* Vessel temperature is measured with a side-inserted PT-100 temperature probe and maintained using PID control.
* Control range: 0-125°C, ±0.1°C. Operational range up to 85°C

Agitation

* Manual or automatic control of agitation speed
* 15-step program to change speed, or use DO cascade control

Air supply and exhaust

Gas supply and dehumidifer: uses in-house air compressor or air dehumidifier
* Includes re-useable, autoclavable 0.2μm air filter for gas inlet
* Gas Inlet (air)
    Includes mass flow controller:
    2 vvm maximum according to the vessel capacity
* Gas Inlet (oxygen)
   Includes pure oxygen rotameter (manual flow control):
   1 vvm maximum according to the vessel capacity
* Includes oxygen gas solenoid valve, with automatic pulsed time control

Air outlet / Exhaust
* Exhaust port with stainless steel condenser
* Includes re-useable, autoclavable 0.2μm air filter
* Includes automated adjustable gas outlet valve to adjust vessel back pressure
* Can control manually or automatically via software

Capacity

100 L

200 L

300 L

500 L

1000 L

Power

Three phase 220V or 380V (note: can be customized to local standard)

Air

At least 7 bar

300 L/min

flow rate

600 L/min

flow rate

900 L/min

flow rate

1500 L/min

flow rate

3000 L/min

flow rate

Dehumidified

Oil-free

Peripheral factory water supply

Cooling water (tap water, at least 15oC below working temperature, must be soft water) ;
Pressure at least 2 bar

Process water

RO Water

Plant steam

≥ 2 bar

Process steam

≥ 2 bar

Drain

In situ drain;

≥ 2"

In situ drain;

≥ 2"

In situ drain;

≥ 2"

In situ drain;

≥ 4"

In situ drain;

≥ 4"